Assessing Germline Variations among Black Patients with Early-Onset Prostate Cancer


Students will collaborate with the research team of Dr. Kathleen Cooney, including prominent partners both at Duke and other institutes, to identify genetic variants likely associated with early onset prostate cancer in African American patients identified by the Metropolitan Detroit Cancer Surveillance System (MDCSS) cancer registry. Students will analyze whole exome sequencing data from samples collected from patients to generate a detailed curation of data relating genetic variants to severity of cancer prognosis. This work will provide valuable data for identifying risk factors related to the most frequently diagnosed cancer among men in the United States in a group that is disproportionately affected by earlier onset and more severe prognoses for the condition.

Project Lead: Dr. Kathleen Cooney

Image credit: National Human Genome Research Institute,