The goal of this Data+ project is to apply and extend custom analytics solutions to discover how life remains resilient in extreme environments. An explosion of data has resulted from recent discoveries of tiny single-celled life hiding out in the most extreme places on Earth. These single celled creatures, or microbes, thrive in hot springs at boiling temperatures, in brine lakes saturated with salt, and in deserts once thought to be sterile. Studies in the Schmid lab at Duke have generated large data sets tracking how microbes grow and change their gene expression when faced with extreme stress. However, the majority of these data remain to be analyzed. In this Data+ project, students will apply and extend the statistical models to ask how extreme microbes grow and change during exposure to nutrient deprivation, extreme stress, and genetic mutations.
(photo credit: Peter Tonner et al., 2020 PLoS Computational Biology https://journals.plos.org/ploscompbiol/article/comments?id=10.1371/journal.pcbi.1008366 )
Project Lead: Amy Schmidt
Project Manager: David Buch