Exploring the genetic basis of yeast biofilms

Project Summary

Students learned to visualize high-dimensional gene expression data; understand genetic differences in the context of gene networks; connect genetic differences to physiological outcomes; and perform simple analyses using the R programming language.

Themes and Categories
Paul Bendich

Graduate students: Liana Burghardt and Colin Maxwell, PhD candidates, Biology Department

Faculty instructor: Danielle Armaleo

Course: Collaboration with Dr. Armaleo in Bio 214 (Cellular and Molecular Biology)

Read the report to learn more (PDF).

Related Projects

In this two-day, virtual data expedition project, students were introduced to the APIM in the context of stress proliferation, linked lives, the spousal relationship, and mental and physical health outcomes.

Stress proliferation is a concept within the stress process paradigm that explains how one person’s stressors can influence others (Thoits 2010). Combining this with the life course principle of linked lives explains that because people are embedded in social networks, stress not only can impact the individual but can also proliferate to people close to them (Elder Jr, Shanahan and Jennings 2015). For example, one spouse’s chronic health condition may lead to stress-provoking strain in the marital relationship, eventually spilling over to affect the other spouse’s mental health. Additionally, because partners share an environment, experiences, and resources (e.g., money and information), as well as exert social control over each other, they can monitor and influence each other’s health and health behaviors. This often leads to health concordance within couples; in other words, because individuals within the couple influence each other’s health and well-being, their health tends to become more similar or more alike (Kiecolt-Glaser and Wilson 2017, Polenick, Renn and Birditt 2018). Thus, a spouse’s current health condition may influence their partner’s future health and spouses may contemporaneously exhibit similar health conditions or behaviors.

However, how spouses influence each other may be patterned by the gender of the spouse with the health condition or exhibiting the health behaviors. Recent evidence suggests that a wife’s health condition may have little influence on her husband’s future health conditions, but that a husband’s health condition will most likely influence his wife’s future health (Kiecolt-Glaser and Wilson 2017).

Fluid mechanics is the study of how fluids (e.g., air, water) move and the forces on them. Scientists and engineers have developed mathematical equations to model the motions of fluid and inertial particles. However, these equations are often computationally expensive, meaning they take a long time for the computer to solve.


To reduce the computation time, we can use machine learning techniques to develop statistical models of fluid behavior. Statistical models do not actually represent the physics of fluids; rather, they learn trends and relationships from the results of previous simulation experiments. Statistical models allow us to leverage the findings of long, expensive simulations to obtain results in a fraction of the time. 


In this project, we provide students with the results of direct numerical simulations (DNS), which took many weeks for the computer to solve. We ask students to use machine learning techniques to develop statistical models of the results of the DNS.

Female baboons occasionally exhibit large swellings on their behinds. Although these ‘sexual swellings’ may evoke disgust from human on-lookers, they provide important information to group members about a female’s reproductive state. To figure out what these sexual swellings mean and whether male baboons notice, we need to look at the data.