The sub-thalamic nucleus (STN) within the sub-cortical region of the Basal ganglia is a crucial targeting structure for Deep brain stimulation (DBS) surgery, in particular for alleviating Parkinson’s disease (PD) symptoms. Volumetric segmentation of such small and complex structure, which is elusive in clinical MRI protocols, is thereby a pre-requisite process for reliable DBS targeting. While direct visualization and localization of the STN is facilitated with advanced high-field 7T MR imaging, such high fields are not always clinically available.
Nonnegative matrix factorization (NMF) has an established reputation as a useful data analysis technique in numerous applications. However, its usage in practical situations is undergoing challenges in recent years.The fundamental factor to this is the increasingly growing size of the datasets available and needed in the information sciences. To address this, in this work we propose to use structured random compression, that is, random projections that exploit the data structure, for two NMF variants: classical and separable. In separable NMF (SNMF) the left factors are a subset of the columns of the input matrix. We present suitable formulations for each problem, dealing with different representative algorithms within each one.
Imagine a world where we understand how to detect mental health and developmental problems in early childhood so that we can intervene early in life and prevent future suffering and impairment. This is a challenge that can only be addressed by an interdisciplinary team of computational people with child psychiatrists and neuroscientists who can integrate and mine knowledge from cross-cultural and global data.